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A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS.

TitleA 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS.
Publication TypeJournal Article
Year of Publication2013
AuthorsHall DA, Gaster RS, Makinwa K, Wang SX, Murmann B
JournalIEEE J Solid-State Circuits
Volume48
Issue5
Pagination1290-1301
Date Published2013 May
ISSN0018-9200
Abstract

Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog front- end and a compact ΣΔ modulator (0.054 mm(2)) with 84 dB of dynamic range and an input referred noise of 49 nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacement for optical protein microarrays while also providing real-time kinetics monitoring.

DOI10.1109/JSSC.2013.2245058
Alternate JournalIEEE J Solid-State Circuits
PubMed ID24761029
PubMed Central IDPMC3993911
Grant ListU54 CA119367 / CA / NCI NIH HHS / United States
U54 CA143907 / CA / NCI NIH HHS / United States
U54 CA151459 / CA / NCI NIH HHS / United States