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Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties.

TitleCarbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties.
Publication TypeJournal Article
Year of Publication2020
AuthorsSong G, Kenney M, Chen Y-S, Zheng X, Deng Y, Chen Z, Wang SX, Gambhir SSam, Dai H, Rao J
JournalNat Biomed Eng
Date Published2020 Feb 03
ISSN2157-846X
Abstract

The low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700-1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.

DOI10.1038/s41551-019-0506-0
Alternate JournalNat Biomed Eng
PubMed ID32015409
Grant ListU54CA199075 / / U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) /