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DNA-functionalized MFe2O4 (M = Fe, Co, or Mn) nanoparticles and their hybridization to DNA-functionalized surfaces.

TitleDNA-functionalized MFe2O4 (M = Fe, Co, or Mn) nanoparticles and their hybridization to DNA-functionalized surfaces.
Publication TypeJournal Article
Year of Publication2005
AuthorsRobinson DB, Persson HHJ, Zeng H, Li G, Pourmand N, Sun S, Wang SX
JournalLangmuir
Volume21
Issue7
Pagination3096-103
Date Published2005 Mar 29
ISSN0743-7463
KeywordsAlkylation, Cobalt, DNA, DNA Probes, Gold, Iron, Manganese, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Molecular Structure, Nanostructures, Organophosphonates, Spectrum Analysis, Surface Properties, Temperature
Abstract

Magnetic MFe2O4 (M = Fe, Co, or Mn) nanoparticles with uniform diameters in the 4-20 nm range and with excellent material properties, reported previously, can be rendered soluble in water or aqueous buffers using a combination of alkylphosphonate surfactants and other surfactants such as ethoxylated fatty alcohols or phospholipids. Surfactant-modified oligonucleotides can be incorporated into the particles' organic shell. The particles can withstand salt concentrations up to 0.3 M, temperatures up to 90 degrees C, and various operations such as concentration to dryness, column or membrane separations, and electrophoresis. The particles can be selectively hybridized to DNA-functionalized gold surfaces with high coverages using a two-story monolayer structure. These particles may find valuable applications involving the magnetic detection of small numbers of biomolecules using spin valves, magnetic tunnel junctions, or other sensors.

DOI10.1021/la047206o
Alternate JournalLangmuir
PubMed ID15779990
PubMed Central IDPMC2924586
Grant ListP01 HG000205 / HG / NHGRI NIH HHS / United States
P01 HG000205-190004 / HG / NHGRI NIH HHS / United States