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Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects.

TitleFluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects.
Publication TypeJournal Article
Year of Publication2012
AuthorsFu A, Wilson RJ, Smith BR, Mullenix J, Earhart C, Akin D, Guccione S, Wang SX, Gambhir SS
JournalACS Nano
Volume6
Issue8
Pagination6862-9
Date Published2012 Aug 28
ISSN1936-086X
KeywordsAnimals, Cell Line, Tumor, Fluorescent Dyes, Glioblastoma, Humans, Magnetic Fields, Magnetite Nanoparticles, Materials Testing, Mice, Mice, SCID, Microscopy, Fluorescence, Nanocapsules, Particle Size
Abstract

Early detection and targeted therapy are two major challenges in the battle against cancer. Novel imaging contrast agents and targeting approaches are greatly needed to improve the sensitivity and specificity of cancer theranostic agents. Here, we implemented a novel approach using a magnetic micromesh and biocompatible fluorescent magnetic nanoparticles (FMN) to magnetically enhance cancer targeting in living subjects. This approach enables magnetic targeting of systemically administered individual FMN, containing a single 8 nm superparamagnetic iron oxide core. Using a human glioblastoma mouse model, we show that nanoparticles can be magnetically retained in both the tumor neovasculature and surrounding tumor tissues. Magnetic accumulation of nanoparticles within the neovasculature was observable by fluorescence intravital microscopy in real time. Finally, we demonstrate that such magnetically enhanced cancer targeting augments the biological functions of molecules linked to the nanoparticle surface.

DOI10.1021/nn301670a
Alternate JournalACS Nano
PubMed ID22857784
PubMed Central IDPMC3601027
Grant List1K99EB008558-01 / EB / NIBIB NIH HHS / United States
1U54 CA119367-01 / CA / NCI NIH HHS / United States
K99 EB008558 / EB / NIBIB NIH HHS / United States
U54 CA119367 / CA / NCI NIH HHS / United States