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Formation and properties of magnetic chains for 100 nm nanoparticles used in separations of molecules and cells.

TitleFormation and properties of magnetic chains for 100 nm nanoparticles used in separations of molecules and cells.
Publication TypeJournal Article
Year of Publication2009
AuthorsWilson RJ, Hu W, Fu CWong Po, Koh ALeen, Gaster RS, Earhart CM, Fu A, Heilshorn SC, Sinclair R, Wang SX
JournalJ Magn Magn Mater
Volume321
Issue10
Pagination1452-1458
Date Published2009 May 1
ISSN0304-8853
Abstract

Optical observations of 100 nm metallic magnetic nanoparticles are used to study their magnetic field induced self assembly. Chains with lengths of tens of microns are observed to form within minutes at nanoparticle concentrations of 10(10) per mL. Chain rotation and magnetophoresis are readily observed, and SEM reveals that long chains are not simple single particle filaments. Similar chains are detected for several 100 nm commercial bio-separation nanoparticles. We demonstrate the staged magnetic condensation of different types of nanoparticles into composite structures and show that magnetic chains bind to immunomagnetically labeled cells, serving as temporary handles which allow novel magnetic cell manipulations.

DOI10.1016/j.jmmm.2009.02.066
Alternate JournalJ Magn Magn Mater
PubMed ID20161001
PubMed Central IDPMC2757286
Grant ListU54 CA119367 / CA / NCI NIH HHS / United States
U54 CA119367-01 / CA / NCI NIH HHS / United States
U54 CA119367-02 / CA / NCI NIH HHS / United States