Title | A Magneto-Nanosensor Immunoassay for Sensitive Detection of Aspergillus Fumigatus Allergen Asp f 1. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Kim D, Wang SX |
Journal | IEEE Trans Magn |
Volume | 48 |
Issue | 11 |
Pagination | 3266-3268 |
Date Published | 2012 Nov 1 |
ISSN | 0018-9464 |
Abstract | We report a magneto-nanosensor biochip for fungal detection. The chip is made of arrays of giant magnetoresistive (GMR) spin-valve sensors, and is able to detect protein biomarkers at low concentrations in solutions. As a demonstration, a standard curve for fungal pathogen Asp f 1 was obtained by measuring signals from various concentrations of Asp f 1 spiked in PBS solutions, indicating a detection limit of ~100 pg/ml. Five positive and negative Asp f 1 solution samples were discriminated correctly in blind experiments. Our data suggest that the magneto-nanosensor biochips are very promising as sensitive diagnostic devices for fungal pathogens. Given the generality of the detection scheme used in the magneto-nanosensor, we anticipate that the platform will be very useful for the detection of many types of biomarkers. |
DOI | 10.1109/TMAG.2012.2195163 |
Alternate Journal | IEEE Trans Magn |
PubMed ID | 23494403 |
PubMed Central ID | PMC3594507 |
Grant List | R21 AI085566 / AI / NIAID NIH HHS / United States |