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A Magneto-Nanosensor Immunoassay for Sensitive Detection of Aspergillus Fumigatus Allergen Asp f 1.

TitleA Magneto-Nanosensor Immunoassay for Sensitive Detection of Aspergillus Fumigatus Allergen Asp f 1.
Publication TypeJournal Article
Year of Publication2012
AuthorsKim D, Wang SX
JournalIEEE Trans Magn
Volume48
Issue11
Pagination3266-3268
Date Published2012 Nov 1
ISSN0018-9464
Abstract

We report a magneto-nanosensor biochip for fungal detection. The chip is made of arrays of giant magnetoresistive (GMR) spin-valve sensors, and is able to detect protein biomarkers at low concentrations in solutions. As a demonstration, a standard curve for fungal pathogen Asp f 1 was obtained by measuring signals from various concentrations of Asp f 1 spiked in PBS solutions, indicating a detection limit of ~100 pg/ml. Five positive and negative Asp f 1 solution samples were discriminated correctly in blind experiments. Our data suggest that the magneto-nanosensor biochips are very promising as sensitive diagnostic devices for fungal pathogens. Given the generality of the detection scheme used in the magneto-nanosensor, we anticipate that the platform will be very useful for the detection of many types of biomarkers.

DOI10.1109/TMAG.2012.2195163
Alternate JournalIEEE Trans Magn
PubMed ID23494403
PubMed Central IDPMC3594507
Grant ListR21 AI085566 / AI / NIAID NIH HHS / United States