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Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer.

TitleModeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsKim D, Lee J-R, Shen E, Wang SX
JournalBiomed Microdevices
Volume15
Issue4
Pagination665-71
Date Published2013 Aug
ISSN1572-8781
KeywordsAnimals, Biological Markers, Biosensing Techniques, Electronics, Environmental Exposure, Magnetic Phenomena, Models, Theoretical, Nanoparticles, Nanotechnology, Neoplasms
Abstract

We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.

DOI10.1007/s10544-012-9678-z
Alternate JournalBiomed Microdevices
PubMed ID22763391
PubMed Central IDPMC3674217
Grant ListR21AI085566 / AI / NIAID NIH HHS / United States
R33CA138330 / CA / NCI NIH HHS / United States
U54 CA143907 / CA / NCI NIH HHS / United States
U54CA143907 / CA / NCI NIH HHS / United States
U54CA151459 / CA / NCI NIH HHS / United States