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Investigation of Circulating Tumor Cells and Cancer Stem Cells (NIH)

Principal Investigators: Shan X. Wang, Heather Wakelee, Alice Fan, Vish Nair
 
Important rare circulating tumor cells (CTC) must be detected in blood at sub-ppb (parts per billion) levels, and their routine preparation from peripheral blood could bring a revolution to solid tumor oncology, similar to the enormous clinical benefits afforded by the ready availability of cells in hematological malignancies.  To address these problems, we are developing micromachined magnetic sifters and programmable magnetic nanoparticles for efficiently capturing and enriching these rare cells and enabling their downstream molecular and single cell analysis.