Jacob Bryan

About Jacob’s Research on Magnetic Nanoparticles for Medicine:

My research is dedicated to the development of magnetic nanoparticles (MNPs) for cutting-edge biomedical applications. My current work focuses on developing MNPs for various medical applications, including significantly improving the resolution and sensitivity of Magnetic Particle Imaging (MPI), an emerging medical imaging modality, by an order of magnitude through the engineering of novel high anisotropy iron oxide-based MNPs. This effort aims to make MPI clinically enabling. My work also involves designing MNPs for single molecule giant magnetoresistance (GMR) detection, which holds significant potential for understanding molecular dynamics in serum. Additionally, I am exploring the application of MNPs in studying CAR-T cell binding kinetics in serum, with the goal of optimizing therapy development and clinical therapy selection. Finally, I am focused on optimizing magnetic materials to enhance the efficiency of magnetic kidney stone extraction, contributing to the development of less cumbersome and more effective treatment. These applications leverage the design of novel iron oxide-based core materials, phase composition, shape anisotropy, and surface chemistries tailored to their respective uses. Through these efforts, I strive to advance the field of biomedical engineering by developing innovative MNP-based technologies that can significantly enhance patient outcomes.