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Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

TitlePeptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
Publication TypeJournal Article
Year of Publication2006
AuthorsCai W, Shin D-W, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X
JournalNano Lett
Volume6
Issue4
Pagination669-76
Date Published2006 Apr
ISSN1530-6984
KeywordsAnimals, Cell Line, Tumor, Coated Materials, Biocompatible, Glioblastoma, Humans, Mice, Mice, Nude, Microscopy, Fluorescence, Neovascularization, Pathologic, Oligopeptides, Particle Size, Quantum Dots, Spectrophotometry, Infrared, Whole Body Imaging
Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

DOI10.1021/nl052405t
Alternate JournalNano Lett.
PubMed ID16608262
Grant List1U54CA119367-01 / CA / NCI NIH HHS / United States
P50 CA114747 / CA / NCI NIH HHS / United States
R21 CA102123 / CA / NCI NIH HHS / United States
R21 EB001785 / EB / NIBIB NIH HHS / United States
R24 CA93862 / CA / NCI NIH HHS / United States