Submitted by Nuvia A. Pacheco on Tue, 02/10/2015 - 23:59
| Title | Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Cai W, Shin D-W, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X |
| Journal | Nano Lett |
| Volume | 6 |
| Issue | 4 |
| Pagination | 669-76 |
| Date Published | 2006 Apr |
| ISSN | 1530-6984 |
| Keywords | Animals, Cell Line, Tumor, Coated Materials, Biocompatible, Glioblastoma, Humans, Mice, Mice, Nude, Microscopy, Fluorescence, Neovascularization, Pathologic, Oligopeptides, Particle Size, Quantum Dots, Spectrophotometry, Infrared, Whole Body Imaging |
| Abstract | We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery. |
| DOI | 10.1021/nl052405t |
| Alternate Journal | Nano Lett. |
| PubMed ID | 16608262 |
| Grant List | 1U54CA119367-01 / CA / NCI NIH HHS / United States P50 CA114747 / CA / NCI NIH HHS / United States R21 CA102123 / CA / NCI NIH HHS / United States R21 EB001785 / EB / NIBIB NIH HHS / United States R24 CA93862 / CA / NCI NIH HHS / United States |
