Skip to content Skip to navigation

Protein-functionalized synthetic antiferromagnetic nanoparticles for biomolecule detection and magnetic manipulation.

TitleProtein-functionalized synthetic antiferromagnetic nanoparticles for biomolecule detection and magnetic manipulation.
Publication TypeJournal Article
Year of Publication2009
AuthorsFu A, Hu W, Xu L, Wilson RJ, Yu H, Osterfeld SJ, Gambhir SS, Wang SX
JournalAngew Chem Int Ed Engl
Volume48
Issue9
Pagination1620-4
Date Published2009
ISSN1521-3773
KeywordsAptamers, Nucleotide, Biosensing Techniques, Magnetics, Microscopy, Electron, Scanning, Nanoparticles, Proteins
Abstract

Direct protein functionalization provides synthetic antiferromagnetic nanoparticles with high chemical specificity and multifunctionality. These nanoparticle-protein conjugates function as improved magnetic labels for biological detection experiments, and exhibit tunable responses to a small external magnetic field gradient, thus allowing the observation of distinctive single nanoparticle motion.

DOI10.1002/anie.200803994
Alternate JournalAngew. Chem. Int. Ed. Engl.
PubMed ID19156803
PubMed Central IDPMC2665302
Grant List1K99 EB008558-01 / EB / NIBIB NIH HHS / United States
1U54 CA119367-01 / CA / NCI NIH HHS / United States
K99 EB008558-01 / EB / NIBIB NIH HHS / United States
U54 CA119367 / CA / NCI NIH HHS / United States
U54 CA119367-01 / CA / NCI NIH HHS / United States