Title | Protein-functionalized synthetic antiferromagnetic nanoparticles for biomolecule detection and magnetic manipulation. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Fu A, Hu W, Xu L, Wilson RJ, Yu H, Osterfeld SJ, Gambhir SS, Wang SX |
Journal | Angew Chem Int Ed Engl |
Volume | 48 |
Issue | 9 |
Pagination | 1620-4 |
Date Published | 2009 |
ISSN | 1521-3773 |
Keywords | Aptamers, Nucleotide, Biosensing Techniques, Magnetics, Microscopy, Electron, Scanning, Nanoparticles, Proteins |
Abstract | Direct protein functionalization provides synthetic antiferromagnetic nanoparticles with high chemical specificity and multifunctionality. These nanoparticle-protein conjugates function as improved magnetic labels for biological detection experiments, and exhibit tunable responses to a small external magnetic field gradient, thus allowing the observation of distinctive single nanoparticle motion. |
DOI | 10.1002/anie.200803994 |
Alternate Journal | Angew. Chem. Int. Ed. Engl. |
PubMed ID | 19156803 |
PubMed Central ID | PMC2665302 |
Grant List | 1K99 EB008558-01 / EB / NIBIB NIH HHS / United States 1U54 CA119367-01 / CA / NCI NIH HHS / United States K99 EB008558-01 / EB / NIBIB NIH HHS / United States U54 CA119367 / CA / NCI NIH HHS / United States U54 CA119367-01 / CA / NCI NIH HHS / United States |