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Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications.

TitleSpin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications.
Publication TypeJournal Article
Year of Publication2006
AuthorsLi G, Sun S, Wilson RJ, White RL, Pourmand N, Wang SX
JournalSens Actuators A Phys
Volume126
Issue1
Pagination98-106
Date Published2006
ISSN0924-4247
Abstract

We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as approximately 23 monodisperse 16-nm superparamagnetic Fe(3)O(4) nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in detection. A patterned self-assembly method of nanoparticles, based on a polymer-mediated process and fine lithography, is developed for the detection. It is found that sensor signal increases linearly with the number of nanoparticles.

DOI10.1016/j.sna.2005.10.001
Alternate JournalSens Actuators A Phys
PubMed ID18414592
PubMed Central IDPMC2293286
Grant ListP01 HG000205 / HG / NHGRI NIH HHS / United States
P01 HG000205-090004 / HG / NHGRI NIH HHS / United States